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It was shown that valproic acid and tobramycin rescued the decreased number of SMN rich structures (gems) in the SMA iPSCs. It is probable that the observed motor neuron death represented a disease relevant phenotype that correlated with the molecular mechanism of SMN reduction. In a follow up study, the pivotal cell death signaling mechanisms in SMA iPSC derived motor neurons were investigated using the original patient iPSC line and a newly generated virus free line from a second SMA patient17..
Fumigatus (vertical) genomes. Axes represent the concatenation of all chromosomes for the corresponding genome. Gridlines indicate the boundaries between chromosomes and axis labels indicate chromosome number. In her 1990 Star Ledger obituary, Vaughn, a Newark native, was called “one of the greatest singing voices of this century.” More than twenty years later, it’s apparent that Vaughn’s voice is one of the greatest in any century. Her voice was so grand that people suggested she’d be equally talented at opera; it was so big that it made her tiny body (she was under five feet tall) seem even smaller by comparison. After winning an Apollo contest for amateur performers, Vaughn started working in Earl Hines’s and Billy Eckstine’s jazz bands.
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